Lovastatin
CAS 75330-75-5
Visão geral
Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. Its use is recommended together with lifestyle changes. It is taken by mouth
A Anant Labs fabrica e fornece impurezas de Lovastatin de alta qualidade para o mercado global. Nossas impurezas EP de Lovastatin são utilizadas por fabricantes de APIs e empresas farmacêuticas totalmente integradas em todo o mundo.
Dados Técnicos
CAS75330-75-5
Fórmula Mol.C24H36O5
Peso Mol.404.547 g/mol
IUPAC[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
SMILESCC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
InChIInChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Chave InChIPCZOHLXUXFIOCF-BXMDZJJMSA-N
Sinônimos
lovastatin75330-75-5mevinolinMevacorAltoprevMevlorSivlorAltocorMK-803Monacolin KLovastatine6alpha-MethylcompactinLovastatinaMevinacorLovastatinum [Latin]6-alpha-MethylcompactinLovastatinumMK 803DTXSID50207849LHU78OQFDNSC-758662(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoateL-154803C10AA022beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoateDTXCID50784(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrateCHEBI:403036-MethylcompactinNSC633781Lovastatinum (Latin)(1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-2-Methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester(S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactoneButanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-1 alpha-Isomer Lovastatin6 Methylcompactin(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoateMK803alpha-Isomer Lovastatin, 1ML-530BMevinacor 10Mevinacor 40((1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) (2S)-2-methylbutanoate(S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-oneLovastatin, 1 alphaRefChem:5964(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl Ester(8-(2-(4-hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate616-212-7((1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) (2R)-2-methylbutanoateLovalordNergadanArteinLovastatine [French]Lovastatina [Spanish]LovalipHipovastinLovasterolCholestraClosterolColevixHipolipLestatinLipivasLipofrenLovastinLozutinPascholRodatinRovacorTecnolipTeroltratBelvasLipdipTaucorbutanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-Lovastatin [USAN]MLS000069585Lovastatin (Standard)6.alpha.-MethylcompactinMSD 803MFCD00072164SMR000058779(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoateC24H36O5(S)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoateHSDB 6534NCGC00023509-03Liposcler6 alpha-MethylcompactinRextatMonakolin KLovastatin (Mevacor)(+)-mevinolin(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoateMevacor (TN)CHEMBL503Lovastatin & PrimycinLovastatin (USP/INN)SR-05000001880UNII-9LHU78OQFDSimvastatin EP Impurity EBRN 3631989TancorCCRIS 8092Mevinacor;Lipofren;Nergadan;Mevacor;Lovastatin CRSMonacolin K;1cqpLovastatin [USAN:USP:INN:BAN](2S)-2-METHYLBUTANOIC ACID (1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-(2-((2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL)ETHYL)-1-NAPHTHALENYL ESTER(2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl esterButanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-Prestwick_819CAS-75330-75-5Mevinolin (lovastatin)LOVASTATIN [MI]LOVASTATIN [INN]Opera_ID_1578Prestwick0_000516Prestwick1_000516Prestwick2_000516Prestwick3_000516Spectrum3_001873Spectrum5_001294Lovastatin (MK-803)LOVASTATIN [HSDB]LOVASTATIN [VANDF]EC 616-212-7LOVASTATIN [MART.]SCHEMBL3136LOVASTATIN [USP-RS]LOVASTATIN [WHO-DD]US9115116, lovastatinBIDD:PXR0113BSPBio_000471BSPBio_001265BSPBio_00334674133-25-8cid_53232MLS001055358MLS006011867US9353061, LovastatinaBIDD:GT0749DivK1c_001032SPECTRUM1503977SPBio_002392BPBio1_000519GTPL2739Lovastatin - Bio-X trade markMEGxm0_000398orb1309414orb3139800LOVASTATIN [ORANGE BOOK]ACon0_000534ACon1_000390BDBM34168HMS503O05HY-N0504RKBio1_001032KBio3_002848LOVASTATIN [EP MONOGRAPH]Simvastatin impurity, lovastatin-NINDS_001032GLXC-06458HMS1569H13HMS1792O07HMS1923O13HMS1990O07HMS2089M06HMS2093O03HMS2096H13HMS2236F07HMS3039N16HMS3259F10HMS3268C03HMS3403O07HMS3412H19HMS3676H19HMS3713H13HMS3884B03LOVASTATIN [USP MONOGRAPH]Pharmakon1600-01503977ADVICOR COMPONENT LOVASTATINALBB-027272HY-N0504MK-803; LOVALIP; MEVACORMSK10235Tox21_110888Tox21_201475Tox21_300268BBL024473CCG-39627EBC-02080NSC758662NSC779704s2061SBB080686STK801953AKOS005267139Lovastatin for peak identification CRSLovastatin; Simvastatin EP Impurity ETox21_110888_1CS-1990DB00227FH24950KS-1082Mevinolin from Aspergillus sp., powderNC00713NSC 758662NSC-633781NSC-779704IDI1_001032NCGC00023509-04NCGC00023509-05NCGC00023509-06NCGC00023509-07NCGC00023509-08NCGC00023509-09NCGC00023509-10NCGC00023509-11NCGC00023509-13NCGC00023509-14NCGC00023509-16NCGC00023509-25NCGC00254157-01NCGC00259026-01AC-13961BL164644Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-G226SMR000673570SBI-0051881.P002CS-0694830L0214NS00000544SIMVASTATIN IMPURITY E [EP IMPURITY]EN300-52515C07074D00359M02056AB00052400-17AB00052400_18AB00052400_19Mevinolin from Aspergillus sp., >=98% (HPLC)Q417740SR-01000000123SR-01000000123-3SR-05000001880-1SR-05000001880-2BRD-K09416995-001-06-8BRD-K09416995-001-21-7BRD-K09416995-001-38-1BRD-K09416995-001-39-9BRD-K09416995-001-40-7Mevacor;Monacolin K;mevinolin;6-alpha-MethylcompactinSIMVASTATIN IMPURITY, LOVASTATIN- [USP IMPURITY]Z754931258(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-8-(2-((4R,6R)-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl)-3,7-dimethylnaphtyl(S)-2-methylbutyrat(S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-((3R,5R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl ester1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate8-[2-((2R,4R)-4-hydroxy-6-oxo(2H-3,4,5-trihydropyran-2-yl))ethyl](1S,7S,8S,3R, 8aR)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthyl (2S)-2-methylbutanoateButanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-BUTANOIC ACID, 2-METHYL-, 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-(2-(TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL)ETHYL)-1-NAPHTHALENYL ESTER, (1S-(1.ALPHA.(R*),3.ALPHA.,7.BETA.,8.BETA.(2S*,4S*),8.ALPHA..BETA.))-